TLC and DLC Test ā€“ An Overview

What is the TLC & DLC Test?

Total Leukocyte Count & Differential Leukocyte Count Test.

Leukocytes, also known as white blood cells (WBCs), are blood cells that are essential components of the body’s immune system. WBCs are classified into five categories, each with a distinct function: neutrophils, basophils, eosinophils, monocytes, and lymphocytes.

Lymphocytes are further classified into three types: B-lymphocytes, T-lymphocytes, and natural killer (NK) cells. Granulocytes are neutrophils, basophils, and eosinophils that have granules in their cytoplasm.

A persistently increased WBC count may be an indicator of a chronic illness that is not resolving normally and may require immediate treatment.

The TLC & DLC is done:

  • As a part of Complete Blood Count (CBC) Test in routine health checkups.
  • To diagnose infections and inflammation.
  • To diagnose conditions that decrease WBC count like bone marrow disorders.
  • To monitor bone marrow function.

Inform your doctor about any drugs you are currently taking. Unless otherwise directed by your doctor, no extra preparations are necessary.

A blood sample is used for the test. A needle is used to take blood from a vein in your arm or hand. It’s routinely performed at a hospital, clinic, or lab. Home collection services are now offered as well. A qualified phlebotomist, nurse, or medical assistant will come to your home to safely take your blood sample.

Keep the following considerations in mind:

  • You may notice a minor bruise at the puncture site.
  • Slight pain in the arm after the test, which can last for a few days.

There is usually no risk associated with the TLC & DLC Test.

The total leukocyte count (TLC) is a measurement of the total number of white blood cells (WBCs) in a given volume of blood.

The percentage of different types of WBCs is determined by the Differential Leukocyte Count (DLC).

Reference Range:

The reference range for the TLC & DLC test is listed in the table below:

TLC Tests Normal Range
At birth 10,000-25,000/cu mm
1-3 years 6,000-18,000/cu mm
HDL 45 ā€“ 60 mg/dL
4-7 years 6,000-15,000/cu mm
8-12 years 4,500-13,500/cu mm
Adults 4000-10500/cu mm
DLC Tests Normal Range
Neutrophils 40-80 %
Lymphocytes 20-40%
Eosinophils 1-6%
Monocytes 2-10%
Basophils 0-1%
Adults 4000-10500/cu mm

Aside from age, the normal range of leukocyte count is determined by a variety of parameters such as gender, health state, prior instances of sickness, vaccines, and so on. The range also slightly varies significantly amongst laboratories that perform the test.


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Understanding TLC & DLC Test Results

An Increase in TLC of more than 10,000/cu mm is known as leukocytosis and a decrease of less than 4,000/cu mm as leucopenia.

Leukocytosis is observed in –
Inflammatory conditions such as rheumatoid arthritis, allergies, cancers such as leukemia, myeloproliferative neoplasm.
Conditions causing necrosis (tissue death) such as severe burns, trauma, surgery, etc.
Cigarette smoking, allergy, very heavy physical exercise, pregnancy, certain drugs such as corticosteroids, epinephrine, heparin, lithium, etc.

Leukopenia is observed in –
Bone marrow depression caused by poisons, radiation, or chemotherapy.
Bone marrow illnesses that limit leukocyte production, such as myelodysplastic syndrome, vitamin B12 or folate deficiency, leukemia, etc.

Neutrophil Count:
Decreased levels (Neutropenia) are observed in aplastic anemia, autoimmune disorders, drug reactions or chemotherapy.
Increased levels (Neutrophilia) are observed in acute bacterial infections, inflammation, burns.

Lymphocyte Count
Decreased levels (Lymphopenia) are observed in bone marrow damage, aplastic anemia, autoimmune disorders.
Increased levels (Lymphocytosis) are observed in acute viral infections, tuberculosis, lymphocytic leukemia.

Monocyte Count
Decreased levels are rare and medically insignificant.
Increased levels (Monocytosis) are observed in chronic infections like tuberculosis, bacterial endocarditis, collagen vascular disorders, inflammatory bowel diseases.

Eosinophil Count
Decreased levels are rare and medically insignificant.
Increased levels (Eosinophilia) are observed in asthma, allergies, drug reactions, parasitic infections.

Basophil Count
Decreased levels are rare and medically insignificant.
Increased levels (Basophilia) are observed in chronic myeloid leukemia (CML).
WBC count in the blood can be influenced by illnesses other than infection or inflammation, such as immune system disorders, autoimmune conditions, cancer, and so forth. In some instances, one or more categories of WBC count may be greater or lower than usual.
The Differential Leukocyte Count Test indicates a disease affecting the body. Additional tests are conducted to confirm a specific ailment and direct therapy.


Instructions To Book an Appointment

The details about this test mentioned on our website are for reference purpose only. It is recommended to contact a doctor for interpreting and understanding the test reports. Instead of searching ' TLC DLC TEST' on the web, all you need to do is, visit our website and book the TLC and DLC test online. Just enter your mobile number or mail, generate an OTP, add your details, and schedule your appointment. No documents are needed at the time of booking; a few basic details are all we want. Also, we offer contactless doorstep collection services as well.

You can also book the appointment for your test by dialing our customer care number i.e. +91-124-4967000.

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